Royal Thai Air Force Air Chief Marshal Prajin Juntong visits S'pore

SINGAPORE: Commander-in-Chief of the Royal Thai Air Force (RTAF) Air Chief Marshal (ACM) Prajin Juntong is in Singapore on a three-day introductory visit.

He called on Senior Minister of State for Defence Mr Chan Chun Sing at the Ministry of Defence (MINDEF) on Monday afternoon.

ACM Prajin had earlier called on Chief of Air Force Major-General Ng Chee Meng after inspecting a Guard of Honour.

ACM Prajin will co-officiate the opening ceremony of Exercise Cope Tiger on Tuesday. Exercise Cope Tiger is an annual trilateral exercise conducted by the air forces of Singapore, Thailand and the United States.

MINDEF said ACM Prajin's visit underscores the close and long-standing defence ties shared between Singapore and Thailand.

The Republic of Singapore Air Force and the RTAF interact regularly through exercises, professional exchanges, and courses. These interactions have bolstered the friendship and mutual understanding among the personnel of the two air forces, said MINDEF.

- CNA/jc

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NFL Week 15: The best photos

The Jacksonville Jaguars observe a moment of silence to honor the victims of the Connecticut school shooting before their game against the Miami Dolphins at Sun Life Stadium on Sunday, December 16. Check out the action from Week 15 of the NFL and then look back at the best photos from Week 14.

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Two Topeka, Kan., police officers slain outside grocery store

Updated 2:05 a.m. EST

TOPEKA, Kan. Two Topeka Kansas police officers were fatally shot outside a grocery store Sunday while responding to a report of a suspicious vehicle, authorities said.

Topeka Police Chief Ronald Miller called the shootings of Cpl. David Gogian and Officer Jeff Atherly "unspeakable." He said both Gogian, 50, and Atherly, 29, were shot in the head by a gunman who opened fire on them within minutes of their arrival to investigate the vehicle.

"It's clearly beyond words. It's unspeakable almost about why this happens and why this is happening in America at this stage in our history," Miller said.

Police were searching for a 22-year-old man believed to have been the one who fired on the officers from the vehicle. He remained at large Sunday night. Miller didn't know the motive for the shooting but said the suspect has a criminal history, though he wouldn't elaborate.

A third officer who went to the scene to check on the vehicle was not injured in the shooting.

Gogian and Atherly were taken to a hospital and later pronounced dead.

The call about the vehicle came shortly after 6 p.m. Sunday, police said. Gogian and Atherly had arrived as backup for another officer when someone in the vehicle they were investigating started shooting.

"I don't believe they had any idea this situation was going to go this direction as quickly as it did," Miller said.

A witness told CBS Topeka affiliate WIBW-TV he heard three gun clips emptied, then heard another series of shots.

The station says a neighbor told the Topeka Capital-Journal he heard several shots fired.

He said there was more than one person in the vehicle, which later was found outside a house about 10 blocks from the grocery store. Officers searched the home but didn't find the shooting suspect.

The chief declined to say why officers were investigating the vehicle and why it was considered suspicious.

A small crowd met for a candlelight vigil Sunday night outside police headquarters after hearing about the shooting. As the group gathered, police officials announced to reporters nearby that the officers had died.

Gogian started with the Topeka Police Department in September 2004. Atherly had been with the department since April 2011.

Miller said Gogian was a retired military serviceman. It wasn't immediately clear what branch of the military. He has a son who's also a Topeka police officer.

"He had spent his life in service to his country and in the city of Topeka," the chief said.

Meanwhile, Atherly was "just getting started" in his career, he said.

The last time a Topeka officer was killed in the line of duty was 2000, and it's been longer than that, since 1995, that one was fatally shot on the job.

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Obama: Nation Faces 'Hard Questions' After Shooting

President Barack Obama said at an interfaith prayer service in this mourning community this evening that the country is "left with some hard questions" if it is to curb a rising trend in gun violence, such as the shooting spree Friday at Newtown's Sandy Hook Elementary School.

After consoling victims' families in classrooms at Newtown High School, the president said he would do everything in his power to "engage" a dialogue with Americans, including law enforcement and mental health professionals, because "we can't tolerate this anymore. These tragedies must end. And to end them we must change."

Mandel Ngan/AFP/Getty Images

President Obama: 'Newtown You Are Not Alone' Watch Video

Sandy Hook Elementary Shooting: Remembering the Victims Watch Video

The president was not specific about what he thought would be necessary and did not even use the word "gun" in his remarks, but his speech was widely perceived as prelude to a call for more regulations and restrictions on the availability of firearms.

The grieving small town hosted the memorial service this evening as the the nation pieces together the circumstances that led to a gunman taking 26 lives Friday at the community's Sandy Hook Elementary School, most first graders.

"Someone once described the joy and anxiety of parenthood as the equivalent of having your heart outside your body all of the time, walking around," he said, speaking of the joys and fears of raising children.

"So it comes as a shock at a certain point when you realize no matter how much you love these kids you can't do it by yourself," he continued. "That this job of protecting kids and teaching them well is something we can only do together, with the help of friends and neighbors, with the help of a community, and the help of a nation."

CLICK HERE for Full Coverage of the Tragedy at Sandy Hook

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How human biology can prevent drug deaths

Thousands of people die from adverse effects of medicines that have been tested on animals. There is a better way, say geneticist Kathy Archibald and pharmacologist Robert Coleman

ADVERSE drug reactions are a major cause of death, killing 197,000 people annually in the European Union and upwards of 100,000 in the US. Little coverage is given to such grim statistics by governments or pharmaceutical companies, so patients and their doctors are not primed to be as vigilant as they should be, and adverse drug reactions (ADRs) remain seriously under-recognised and under-reported.

The €5.88-million EU-ADR project, which published its final report in October, showed that it is possible to spot these reactions earlier by applying data-mining techniques to electronic health records. These techniques could, for example, have detected the cardiovascular risk signals of arthritis drug Vioxx three years before the drug was withdrawn in 2004 - saving many tens of thousands of lives. But invaluable as such systems are, it would be even better to detect risk signals before a drug reaches humans, thus saving even more lives.

Currently, 92 per cent of new drugs fail clinical trials, even though they have successfully passed animal tests. This is mostly because of toxicity, which can be serious and even fatal for the people taking part in the trials. For example, in 2006, six people enrolled in a UK trial of the drug TGN1412 were hospitalised after developing multiple organ failure. Many clinical trials are now conducted in India, where, according to India's Tribune newspaper, at least 1725 people died in drug trials between 2007 and 2011. Clearly, there is an urgent need for better methods to predict the safety of medicines for patients as well as volunteers in clinical trials.

At the patient safety charity, Safer Medicines, we believe this goal is most likely to be achieved through a greatly increased focus on human, rather than animal, biology in preclinical drugs tests. New tests based on human biology can predict many adverse reactions that animal tests fail to do, and could, for example, have detected the risk signals produced by Vioxx, which in animal studies appeared to be safe, and even beneficial to the heart.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed "patient in a dish"); "body on a chip" devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy. Then there are the more humble but no less valuable studies in ethically donated "waste" tissue.

These innovations promise precious insights into the functioning of the integrated human system. Many are already commercially available, but they are not being embraced with the enthusiasm they merit.

Pharmaceutical companies would make much greater use of them if governments encouraged it, but inflexible requirements for animal tests is a major deterrent. Ever since the thalidomide birth-defects tragedy, animal testing has been enshrined in law worldwide, despite the irony that more animal testing would not have prevented the release of thalidomide, because the drug harms very few species.

So how well have animal tests protected us? Many studies have calculated the ability of animal tests to predict adverse reactions to be at or below 50 per cent. In 2008, a study in Theriogenology (vol 69, p 2) concluded: "On average, the extrapolated results from studies using tens of millions of animals fail to accurately predict human responses." And a recent study in Regulatory Toxicology and Pharmacology (vol 64, p 345) shows that animal tests missed 81 per cent of the serious side effects of 43 drugs that went on to harm patients.

It is hard to understand why governments defend a system with such a poor record, or why they are dismissive of new technologies that promise increased patient safety while decreasing the time and cost of drug development, not to mention the savings to healthcare systems from fewer adverse drug reactions. Proposals to compare human-based tests with animal-based approaches have been strongly supported by members of the UK parliament. The Early Day Motions they signed were among the most-signed of all parliamentary motions between 2005 and 2006, 2008 and 2009, and 2010 and 2012.

Safer Medicines has put these concerns to the UK Department of Health and the prime minister - to be told that "human biology-based tests are not better able to predict adverse drug reactions in humans than animal tests".

It is a tragedy that so many suffer or die through the use of inadequately tested drugs when tests based on human biology are readily available. Yet governments continue to mandate animal tests, despite the lack of a formal demonstration of fitness for purpose, and a growing global realisation among scientists that animal toxicity tests are inadequate and must be replaced.

In its 2007 report, Toxicity Testing in the 21st Century: A Vision and a Strategy, the US National Research Council called for the replacement of animal tests: "The vision for toxicity testing in the 21st century articulated here represents a paradigm shift from the use of experimental animals... toward the use of more efficient in vitro tests and computational techniques." To its credit, the US government is at least working on initiatives to hasten this. The UK government, however, still denies there is a problem. How many must die before it listens?

Kathy Archibald is director of the Safer Medicines Trust. She is a geneticist who worked in the pharmaceutical industry.

Robert Coleman is a pharmacologist with pharmaceutical industry experience. He is now a drug discovery consultant and adviser to the trust

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Resolution of stalled upgrading works at Rivervale Plaza one key priority: DPM

SINGAPORE: Deputy Prime Minister Teo Chee Hean has said that one of the priorities he wants to tackle for Punggol East residents is the resolution of upgrading works at Rivervale Plaza.

Works there have been delayed because the contractor has gone bust.

Mr Teo, who is also the anchor minister for Pasir Ris-Punggol GRC, was speaking to reporters on the sidelines of a community event on Sunday.

The Deepavali celebration is the second community event Mr Teo attended over the weekend, following the resignation of Punggol East MP Michael Palmer over an extramarital affair.

Mr Teo noted that one of the concerns of residents is the upgrading works at Rivervale.

He said his team of MPs will continue discussions, started by Mr Palmer, with the Housing and Development Board, residents and shop owners, to resolve the problem.

Mayor Teo Ser Luck has been appointed caretaker MP for Punggol East.

Mr Teo Chee Hean said: "We've always looked after the residents (of Punggol East) as a larger Pasir Ris-Punggol family. So I know quite a lot of the grassroots leaders here. I've been here many times also, with Mr Teo Ser Luck as well. So we will continue looking after residents."

DPM Teo has said he will attend the ward's Meet-the-People session on Monday night.

- CNA/ir

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Pearlman: I think Bobby Petrino is slime

Bobby Petrino was named head coach at Western Kentucky, months after being embroiled in scandal at University of Arkansas

STORY HIGHLIGHTS

• Bobby Petrino was named the new football coach at Western Kentucky this week


• Hiring came just months after he was fired from Arkansas amid scandal


• Jeff Pearlman says, sadly, this is no surprise in big-time college sports


• He says the vast majority of players are ultimately hurt by the behavior of coaches and administrators

Editor's note: Jeff Pearlman is the author of 'Sweetness: The Enigmatic Life of Walter Payton.' He blogs at jeffpearlman.com. Follow him on Twitter.

(CNN) -- I have a dog named Norma.

She is a small beige cockapoo who barks at the mailman.

I would not trust Bobby Petrino to watch her.

Jeff Pearlman

I also would not trust Bobby Petrino to take my car in for a tire change. I would not trust Bobby Petrino to deposit my Aunt Ruth's Social Security check. I wouldn't trust him to clean my bowling ball, shop for a Christmas ham, change a twenty for two tens, tell me the time or recite the proper lyrics to Blind Melon's "No Rain."

This is not because I am a particularly untrusting person.

No, it's because I think Bobby Petrino is slime.

In case you missed the news, two days ago Western Kentucky University held a press conference to announce that Petrino, undeniably one of the nation's elite football minds, had agreed to a four-year, $850,000 per year deal to take over the Hilltoppers.

With nearly 400 giddy sports fanatics in attendance, Petrino, standing alongside Todd Stewart, the school's athletic director, spoke of honor and loyalty and love and redemption. The ensuing press release, issued by Western Kentucky's sports information department, was straight out of Disney: 101. It made Petrino sound like a cross between Vince Lombardi, Martin Luther King and Gandhi; God's gift to young men seeking to better themselves.

Petrino fired as Arkansas head football coach

What it failed to mention—and what the school desperately wants everyone to fail to mention—is that Petrino may well be the least ethically whole man in the, ahem, ethically whole-deprived world of Division I collegiate sports.

Why, it was only seven months ago that Petrino, at the time the University of Arkansas' head coach, was riding his motorcycle when he crashed along Highway 16 near Crosses, Arkansas.

When asked by school officials to explain what had happened, he failed to mention that, eh, also on the bike was Jessica Dorrell, a 26-year-old former Razorbacks volleyball player who worked as the student-athlete development coordinator for the football program. It turned out that Petrino, a married father of four, was not only having an affair with Dorrell (who was engaged at the time), but was a key voice on the board that hired her for the position when she wasn't even remotely qualified.

During an ensuing university investigation, it was determined that Petrino made a previously undisclosed $20,000 cash gift to Dorrell as a Christmas present.

Ho, ho, ho.

To his credit, Jeff Long, the school's athletic director, defied the wishes of every pigskin-blinded Razorback fan and fired Petrino. In a statement, he rightly wrote that, "all of these facts, individually and collectively, are clearly contrary to character and responsibilities of the person occupying the position of the Head Football Coach—an individual who should serve as a role model and a leader for our student-athlete."

Now, ethics and morals and character be damned, Bobby Petrino has returned, spewing off nonsense about second chances (Ever notice how garbage men and bus drivers rarely get the second chances we are all—according to fallen athletic figures—rightly afforded as Americans?) and learning from mistakes and making things right.

Western Kentucky, a school with mediocre athletics and apparently, sub-mediocre standards, has turned to a person who lied to his last employer about the nature of an accident involving the mistress he allegedly hired to a university position she was unqualified to hold. Please, if you must, take a second to read that again. And again. And again.

Bobby Petrino, holder of a Ph.D. in the Deceptive Arts (he also ditched the University of Louisville shortly after signing a long-term extension in 2007, and quit as coach of the Atlanta Falcons 13 game into his first season later that year. He informed his players via a note atop their lockers), will be the one charged with teaching the 17- and 18-year-old boys who decide to come to Bowling Green about not merely football, but life. He will be their guide. Their compass. Their role model.

Bobby Petrino and social media prove a bad mix

Sadly, in the world of Division I sports, such is far from surprising. This has been a year unlike any other; one where the virtues of greed and the color of green don't merely cloak big-time college athletics, but control them. In case you haven't noticed, we are in the midst of a dizzying, nauseating game of Conference Jump, where colleges and universities—once determined to maintain geographic rivals in order to limit student travel—have lost their collective minds.

The University of Maryland, a charter member of the ACC, is headed for the Big Ten. The Big East—formerly a power conference featuring the likes of Syracuse, Georgetown, St. John's and Connecticut—has added Boise State, San Diego State, Memphis, Houston, Southern Methodist and Navy. Idaho moved from the WAC to the Big Sky, Middle Tennessee State and Florida Atlantic went to Conference USA, the University of Denver—a member of the WAC for approximately 27 minutes—joined the Summit League. Which, to be honest, I didn't even know existed.

Rest assured, none of these moves (literally, nary a one) were conducted with the best interests of so-called student-athletes in mind. New conferences tend to offer increased payouts, increased merchandising opportunities, increased exposure and increased opportunities to build a new stadium—one with 80,000 seats, 100 luxury boxes, $20 million naming rights, $9 hot dogs and the perfect spot for ESPN to broadcast its Home Depot pregame show.

Why, within 24 hours of quarterback Johnny Manziel winning the Heisman Trophy, Texas A&M was hawking Heisman T-shirts for $24 on its website (Or, for a mere $54.98, one can purchase his No. 2 jersey).

Percentage of the dough that winds up in Manziel's pocket? Zero.

After another spectacular exit, Petrino eyes football return

That, really, is the rub of it all; of Petrino's crabgrass-like revival; of coaches bounding from one job for another (even as players can only do so after sitting out a year); of Rutgers moving west and San Diego State moving east and athletic department officials moving on up (to a penthouse apartment in the sky); of $54.98 jerseys.

It's the athletes ultimately getting screwed.

Sure, for the 0.5% of Division I football players who wind up in the NFL, the deal is a sweet one. The other 99.5%, however, are mere pawns, sold a dizzying narrative of glory and fame and lifelong achievement, but, more often than not, left uneducated, unfulfilled and physically battered.

They are told a coach will be with them for four years—then watch as said figure takes a $2 million gig elsewhere but, hey, only because it was right for him and his family.

They are told they will receive a great education, then find themselves stuck on a six-hour flight from California to Newark, New Jersey. They are told that these will be the greatest years of their life, that the college experience is a special one, that only the highest of standards exist.

Then they meet their new coach: Bobby Petrino.

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The opinions expressed in this commentary are solely those of Jeff Pearlman.

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Conn. dad recalls loving, creative 6-year-old

NEWTOWN, Conn. Fighting back tears and struggling to catch his breath, the father of a 6-year-old gunned down in Friday's school shooting in Connecticut told the world about a little girl who loved to draw and was always smiling, and he also reserved surprising words of sympathy for the gunman.

Robbie Parker's daughter Emilie was among the 20 children who died in the one of the worst attacks on schoolchildren in U.S. history. He was one of the first parents to speak publicly about their loss.

"She was beautiful. She was blond. She was always smiling," he said.

Parker spoke to reporters not long after police released the names and ages of the victims, a simple document that told a horrifying story of loss.

He expressed no animosity, said he was not mad and offered sympathy for family of the man who killed 26 people and himself.

To the man's family, he said, "I can't imagine how hard this experience must be for you."

He said he struggled to explain the death to Emilie's two siblings, 3 and 4.

"They seem to get the fact that they have somebody they're going to miss very much," he said.

Parker said his daughter loved to try new things — except for new food. And she was quick to cheer up those in need.

36 Photos

Vigils for Conn. school shooting victims

"She never missed an opportunity to draw a picture or make a card for those she around her," he said.

The world is a better place because Emilie was in it, he said.

"I'm so blessed to be her dad," he said.

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Conn. Victim's Father Remembers 'Loving' Daughter

(Image credit: Emilie Parker Fund/Facebook)

Emilie Parker, the little girl with the blond hair and bright blue eyes, would have been one of the first to comfort her classmates at Sandy Hook Elementary School, had a gunman’s bullets not claimed her life, her father said.

“My daughter Emilie would be one of the first ones to be standing and giving support to all the victims because that’s the kind of kid she is,” her father, Robbie Parker said as he fought back tears, telling the world about his “bright, creative and loving” daughter who was one of the 20 young victims in the Newtown, Conn., shooting.

“She always had something kind to say about anybody,” her father said.  ”We find comfort reflecting on the incredible person Emilie was and how many lives she was able to touch.”

Emilie, 6, was helping teach her younger sisters to read and make things, and she was the little girls would go to for comfort, he said.

“They looked up to her,” Parker said.

READ: Complete List of Sandy Hook Victims

Parker moved his wife and three daughters to Newtown eight months ago after accepting a job as  a physician’s assistant at Danbury Hospital. He said Emilie, his oldest daughter, seemed to have adjusted well to her new school, and he was very happy with the school, too.

“I love the people at the school. I love Emilie’s teacher and the classmates we were able to get to know,” he said.

      (Image Credit: Alex von Kleydorff/AP Photo)

The family dealt with another tragic loss in October when Emilie lost her grandfather in an accident.

“[This] has been a topic that has been discussed in our family in the past couple of  months,” Parker said. “[My daughters ages 3 and 4] seem to get the idea that there’s somebody who they will miss very much.”

Emilie, a budding artist who carried her markers and pencils everywhere, paid tribute to her grandfather by slipping a special card she had drawn into his casket, Parker said.  It was something she frequently did to lift the spirits of others.

“I can’t count the number of times Emilie would find someone feeling sad or frustrated and would make people a card,” Parker said. “She was an exceptional artist.”

The girl who was remembered as “always willing to try new things, other than food” was learning Portuguese from her father, who speaks the language.

(Image Credit: Emilie Parker Fund/Facebook)

On Friday morning, Emilie woke up before her father left for his job and exchanged a few sentences with him in the language.

“She told me good morning and asked how I was doing,” Parker said. “She said she loved me, I gave her a kiss and I was out the door.”

Parker found out about the shooting while on lockdown in Danbury Hospital and found a television for the latest news.

“I didn’t think it was that big of deal at first,” he said. “With the first reports coming in, it didn’t sound like it was going to be as tragic as it was. That’s kind of what it was like for us.”

CLICK HERE for full coverage of the Sandy Hook shooting.

Parker said he knows that God can’t take away free will and would have been unable to stop the Sandy Hook shooting. While gunman Adam Lanza used his free agency to take innocent lives, Parker said he plans to use his in a positive way.

“I’m not mad because I have my  [free] agency to use this event to do whatever I can to make sure my family and my wife and my daughters are taken care [of],” he said. “And if there’s anything I can do to help to anyone at any time at anywhere, I’m free to do that.”

(Image credit: Emilie Parker Fund/Facebook)

Friday night, hours after he learned of his daughter’s death, Parker said he spoke at his church.

“I don’t know how to get through something like this. My wife and I don’t understand how to process all of this,” he said today. “We find strength in our religion and in our faith and in our family. ”

“It’s a horrific tragedy and I want everyone to know our hearts and prayers go out to them. This includes the family of the shooter. I can’t imagine how hard this experience must be for you and I want you to know our family … love and support goes out to you as well.”

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Zebrafish made to grow pre-hands instead of fins

PERHAPS the little fish embryo shown here is dancing a jig because it has just discovered that it has legs instead of fins. Fossils show that limbs evolved from fins, but a new study shows how it may have happened, live in the lab.

Fernando Casares of the Spanish National Research Council and his colleagues injected zebrafish with the hoxd13 gene from a mouse. The protein that the gene codes for controls the development of autopods, a precursor to hands, feet and paws.

Zebrafish naturally carry hoxd13 but produce less of the protein than tetrapods - all four-limbed vertebrates and birds - do. Casares and his colleagues hoped that by injecting extra copies of the gene into the zebrafish embryos, some of their cells would make more of the protein.

One full day later, all of those fish whose cells had taken up the gene began to develop autopods instead of fins. They carried on growing for four days but then died (Cell, DOI: 10.1016/j.devcel.2012.10.015).

"Of course, we haven't been able to grow hands," says Casares. He speculates that hundreds of millions of years ago, the ancestors of tetrapods began expressing more hoxd13 for some reason and that this could have allowed them to evolve autopods.

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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